Salipro Biotech and partners unlock DEL screening for challenging membrane protein targets

Salipro Biotech announces the latest pre-print of a collaborative study with DyNAbind, AstraZeneca, and the University of Copenhagen, demonstrating a new approach to small‑molecule discovery against difficult membrane protein targets like GPCRs, channels, and transporters.

Using the Salipro® platform, the Salipro team stabilized the membrane channel PANX1 in native‑like lipid nanoparticles, enabling DNA‑Encoded Library (DEL) screening without detergents. The workflow led to the identification of novel PANX1 modulators, validated by SPR, cryo‑EM, and functional electrophysiology.

Congratulations to the authors behind this work: Francesco V. Reddavide, Trine L. Toft‑Bertelsen, Ieva Drulyte, Aspen Gutgsell, Dzung Nguyen, Sara Bonetti, Katerina Vafia, Anne‑Sophie Tournillon, Stephan Heiden, Daniel Grosser, Katarina Iric, Veronica Diez, Nanna MacAulay, Stefan Geschwindner, Michael Thompson, Jens Frauenfeld, and Robin Löving.

The full publication can be accessed at: https://www.biorxiv.org/content/10.64898/2026.01.27.701919v1