Research Highlights

Selected scientific discoveries enabled by the Salipro® platform from our many academic partners

By stabilizing the flexible Spns2 transporter in a detergent-free scaffold, the Salipro® platform enabled the authors to reveals exactly how next-gen inhibitors "lock the gate" against autoimmune signaling.

Chen et al., Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate. Cell (2023)

Unlocking the "Missing Links" of the human S1P transport cycle

Capturing Every State of the alpha-7 nicotinic receptor

When replacing harsh detergents with Salipro® nanoparticles, researchers successfully mapped the full opening and closing mechanism of the α7 receptor for neurological drug discovery.

Noviello et al., Structure and gating mechanism of the α7 nicotinic acetylcholine receptor. Cell (2021)

Unlocking GPCR Dynamics

In this study of the β1-adrenergic receptor (β1AR), Salipro® nanoparticles allow researchers to capture the real-time transitions between active and inactive states of β1AR using NMR, providing a foundation for next-generation drug design.

Chien et al., An Adaptable Phospholipid Membrane Mimetic System for Solution NMR Studies of Membrane Proteins. JACS (2017)

In this publication, the authors used the Salipro® platform to eliminate detergent artifacts to uncover the true "rocker-switch" dynamics and multiple functional states of the SLC37A4 transporter.

Zhou et al., Structural basis of G6P/Pi transport and inhibition in SLC37A4. Nature Structural & Molecular Biology (2025)

Revealing the Real Mechanism of an SLC transporter

Mapping Cancer Metabolism

Using the Salipro® platform, researchers revealed the "mechanistic switch" of Monocarboxylate Transporter 1 (MCT1), providing a structural blueprint for targeting lactate transport in tumor survival.

Xu et al., Embigin facilitates monocarboxylate transporter 1 localization to the plasma membrane and transition to a decoupling state. Cell reports (2022)

A Blueprint for Next-Gen Oncology

Leveraging Salipro® technology to capture four distinct functional states without stabilizing antibodies, researchers have revealed the binding site plasticity of ABCB1, providing a vital structural map to bypass chemotherapy resistance.

Kurre et al., Structural insights into binding-site access and ligand recognition by human ABCB1) EMBO Journal (2025)

Bringing ABC Transporters to Life

In this study, the authors demonstrated how Salipro® nanoparticles prevent the functional suppression of ABC transporters caused by detergent micelles, enabling high-performance biochemical analysis of challenging membrane proteins.

Kanonenberg et al., Functional Reconstitution of HlyB, a Type I Secretion ABC Transporter, in Saposin-A Nanoparticles. Scientific reports (2019)