Research Highlights
Selected scientific discoveries enabled by the Salipro® platform from our many academic partners
By stabilizing the flexible Spns2 transporter in a detergent-free scaffold, the Salipro® platform enabled the authors to reveals exactly how next-gen inhibitors "lock the gate" against autoimmune signaling.
Chen et al., Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate. Cell (2023)
Unlocking the "Missing Links" of the human S1P transport cycle
Capturing Every State of the alpha-7 nicotinic receptor
When replacing harsh detergents with Salipro® nanoparticles, researchers successfully mapped the full opening and closing mechanism of the α7 receptor for neurological drug discovery.
Noviello et al., Structure and gating mechanism of the α7 nicotinic acetylcholine receptor. Cell (2021)
Unlocking GPCR Dynamics
In this study of the β1-adrenergic receptor (β1AR), Salipro® nanoparticles allow researchers to capture the real-time transitions between active and inactive states of β1AR using NMR, providing a foundation for next-generation drug design.
Chien et al., An Adaptable Phospholipid Membrane Mimetic System for Solution NMR Studies of Membrane Proteins. JACS (2017)
