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https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/a44eb226-be65-4889-b441-ee69a3bb5e1e/AZ+2.jpg https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/c2096402-cf34-43fd-bd54-da25bc648d68/Picture+2.jpg https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1599209743018-EDIQBFZ9BFJYK46EGKWK/World%2Bmap%2Bgray.jpg Home - Pushing drug development forward together We work with top-tier pharma and biotech partners to unlock drug targets for drug development programs. https://www.salipro.com/about-us daily 0.75 2024-12-13 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/c6f9706b-50ce-4ff9-afb4-e93e5c1fc432/Jens_transperent.jpg About Us Jens Frauenfeld CEO https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/10f171cc-ef25-4887-b325-b660555d3bc3/Robin_transperent_2.jpg About Us Robin Löving CSO https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/80c13f30-227c-4e05-9334-655b764081b2/Peter_transperent.jpg About Us Peter Jahnmatz Business Development Director https://www.salipro.com/our-technology daily 0.75 2023-02-14 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1598951645707-4XDCTAPY6NC07NQK5F2V/DirectMX.png Our Technology - Salipro® DirectMX™ The Salipro® DirectMX™ technology allows for the direct reconstitution of membrane proteins from crude cell membranes into Salipro particles, opening up new possibilities to explore novel drug targets with their native lipids. Learn more about the Salipro® technology and its applications in our application notes and in peer-reviewed published articles. https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1599665331461-NLI9BJK1565WPOXHJ4HA/Salipro+applications+white.png Our Technology - Salipro® for a wide range of workflows Reconstituting membrane proteins with Salipro opens up the possibility to work with a wide range of downstream applications. https://www.salipro.com/publications daily 0.75 2026-03-13 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1594720601459-FFA9H4R3GGGJM5B29SO3/AN_DirectMX.jpg Publications Salipro® direct membrane extraction https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1594720538273-GE571MYNR4VGM9VAN5LY/AN_SPR.jpg Publications Salipro® for drug screening https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1594720624798-51OKGO7KKZBGRHTG46E3/AN_Ab.jpg Publications Salipro® for antibody discovery https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1629801191970-IMDEXDV7JE7FWNJOCCCW/GEN_PhageDisplay.png Publications - Make it stand out Salipro® for antibody discovery https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/e64ea346-c94a-4cff-8d49-fb5bb69526ab/AN_Pannexin1.png Publications - Make it stand out Salipro® for cryoEM https://www.salipro.com/structure-gallery daily 0.75 2022-04-27 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1603279678130-NHIYAK93J6H5HBL9UMG3/Salipro-GABA+propofol+lipids+2.gif Structure Gallery S. Zhu, et al., Structural and dynamic mechanisms of GABAAreceptor modulators with opposing activities. Nat. Commun. 13, 4582 (2022). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/57dcd02e-417a-4124-aac6-fe97593e6e34/220812+Salipro-GABAA+autoimmune+antibody.png Structure Gallery C. M. Noviello, et al., Structural mechanisms of GABAA receptor autoimmune encephalitis. Cell 185, 2469-2477 (2022). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1598538921928-7GK11T6HSZ87EI5JV8ZB/Picture1+4-3.png Structure Gallery N. X. Nguyen, et al., Cryo-EM structure of a fungal mitochondrial calcium uniporter. Nature 559, 570–574 (2018). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1598608054497-TVU4NZ5GJ0A30OVFX985/Picture5+4-3.png Structure Gallery M. M. Rahman, et al., Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins. Neuron, 1–11 (2020). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1598556444665-3JDHUC6G8DKQBEHHWI1X/Picture3+4-3.png Structure Gallery A. F. Kintzer, et al., Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc. Natl. Acad. Sci. U. S. A. 115, E9095–E9104 (2018). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1598556113595-7B44M2KC4HLG2X22663U/Picture4+4-3.png Structure Gallery A. Gharpure, et al., Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor. Neuron 104, 501-511.e6 (2019). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/10086c66-5a4c-4d3a-81c8-70b441f16f4a/Salipro-alpha7nicotinic_receptor1.png Structure Gallery C. M. Noviello, et al., Structure and gating mechanism of the a7 nicotinic acetylcholine receptor. Cell 184, 1–14 (2021). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1613750142710-89ZN44F82EV8CDV9LUB3/Salipro-5-HT3A_side.png Structure Gallery Y. Zhang, et al., Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers. Nat. Commun. 12, 1074 (2021). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1603280386782-RC6O6O1OXU4YCLJJ7CAT/Salipro-AcrBZ+4-3.png Structure Gallery D. Du, et al., Interactions of a bacterial RND transporter with a transmembrane small protein in a lipid environment. Struct. Des., 1–10 (2020). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1598539350031-WAPC8CWE7WCWCFR6O2FC/Picture2+4-3.png Structure Gallery R. Nagamura, et al., Structural basis for oligomerization of the prokaryotic peptide transporter PepT So2. Acta Crystallogr. Sect. F Struct. Biol. Commun. 75, 348–358 (2019). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/9c5d2d76-53e0-4b5d-9e67-bec9f1280461/Salipro-BAM+side2+PDB+beta-barrel.png Structure Gallery L. Xiao, et al., Structures of the β-barrel assembly machine recognizing outer membrane protein substrates. FASEB J. 35, 1–13 (2021). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/79430c56-2438-49da-87b1-392a79274fe4/Salipro-AdeB+side+4-3.png Structure Gallery A. Ornik-cha, et al., Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms. Nat. Commun. 12, 6919 (2021). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/676bd27a-e8d9-4bb8-92ef-2ff59d5fb38a/Salipro-MsbA.jpg Structure Gallery D.-M. Kehlenbeck, et al., Cryo-EM structure of MsbA in saposin-lipid nanoparticles ( Salipro ) provides insights into nucleotide coordination. FEBS J., 1–12 (2021). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/71567b7d-83ea-40cc-975b-24977f37ff2e/220427+Salipro-NicotinR-tubo+4-3.png Structure Gallery M. M. Rahman, et al., Structural mechanism of muscle nicotinic receptor desensitization and block by curare. Nat. Struct. Mol. Biol. 29, 386–394 (2022). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/7337d2d2-ef7b-47be-ba35-6920c6dac6fb/Salipro-TMEM+4-3.png Structure Gallery C. Wang, M. M. Polovitskaya, B. D. Delgado, T. J. Jentsch, S. B. Long, Gating choreography and mechanism of the human proton-activated chloride channel ASOR. Sci. Adv. 8, 1–13 (2022). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/bf361ce7-d3b3-4050-b7b5-16c3acdcf82d/Salipro+SPNS2.png Structure Gallery H. Chen, et al., Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate. Cell 186, 2644–2655, (2023). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/9bb45c5c-37b3-4ade-b68f-0d67d7c08fa7/221205+Salipro-Mct1-embigin.jpg Structure Gallery Xu et al., Embigin facilitates monocarboxylate transporter 1 localization to the plasma membrane and transition to a decoupling state. Cell Reports 40, 111343 (2022). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/f5db7b39-939a-44af-8658-0e63c4b92f27/Salipro-AtMSL+2.gif Structure Gallery Zhang, J., Maksaev, G. & Yuan, P. Open structure and gating of the Arabidopsis mechanosensitive ion channel MSL10. Nat Commun 14, 6284 (2023). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/7dcf6c03-fabe-4a4e-9344-df65b0e4b133/Salipro-SPNS2-16d.gif Structure Gallery Chen, Hongwen et al. Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate. Cell, Volume 186, Issue 12, 2644 - 2655.e16 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/376229f9-9609-4ff5-9816-b9cecb0ba6f9/Salipro-GABAAR-PPTQ+2.gif Structure Gallery Chojnacka, W., Teng, J., Kim, J.J. et al. Structural insights into GABAA receptor potentiation by Quaalude. Nat Commun 15, 5244 (2024). https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/4e388780-bf38-4bf3-bfd9-945677066a9e/Salipro-5HT3A+tetramer+%281%29.gif Structure Gallery Siavash Mostafavi, Tânia F. Custódio, Katharina E.J. Jungnickel, Christian Löw, Salipro technology in membrane protein research, Current Opinion in Structural Biology, 93, 2025. https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/4ea32f6b-dfc8-4c9a-83b5-befc4beaeb02/Salipro-TauT+inward+open+Taurine+lipids+%281%29.gif Structure Gallery Zhang, H., Cui, N., Ma, X. et al. Structural basis of augmenting taurine uptake by the taurine transporter in alleviating cellular senescence. Cell Res 35, 385–388, 2025 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/d032a11f-e18d-481a-b8ef-1f3c70bb924a/Salipro-1GABAALindahl2024+2.gif Structure Gallery Fan, C., Cowgill, J., Howard, R.J. et al. Divergent mechanisms of steroid inhibition in the human ρ1 GABAA receptor. Nat Commun 15, 7795 (2024) https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/4592293a-3583-49c1-8789-b9636822d087/Salipro-ACA8+E2+Beryllium+Fluoride+2.gif Structure Gallery Sigrid Thirup Larsen, Josephine Karlsen Dannersø, Christine Juul Fælled Nielsen, Lisbeth Rosager Poulsen, Michael Palmgren, Poul Nissen, Conserved N-terminal Regulation of the ACA8 Calcium Pump with Two Calmodulin Binding Sites, Journal of Molecular Biology, Volume 436, Issue 20, 2024, https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/6bfc9d8d-e7eb-47e4-b915-c3c1b176539e/Salipro-ABCB1-Zosuquidar-ATP-Mg+%281%29.gif Structure Gallery Shi Ting Tia, Min Luo, Wenjie Fan, Mapping the Role of P-gp in Multidrug Resistance: Insights from Recent Structural Studies, International Journal of Molecular Sciences 26, 9, (4179), (2025) https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/495dab97-5491-4d0e-b009-d0d957a3418a/Salipro-MprF.gif Structure Gallery Matthew T. K. Hankins et al. ,MprF from Pseudomonas aeruginosa is a promiscuous lipid scramblase with broad substrate specificity. Sci. Adv. 11 (2025) https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/9d01bab2-e584-465b-9bca-8886c2570bed/Salipro-LMCA1+%281%29.gif Structure Gallery Basse Hansen, Sara Flygaard, Rasmus Kock, Magnus Kjaergaard, Poul Nissen, Structure of the [Ca]E2P intermediate of Ca2+-ATPase 1 from Listeria monocytogenes. EMBO ReportsVolume 26, Issue 7 (2025) https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/e8664f73-3342-42f0-99ae-2482e04c1d16/Salipro-SLC33A1-Acetyl-CoA.gif Structure Gallery Zhou, D., Chen, N., Huang, S. et al. Mechanistic insights into the acetyl-CoA recognition by SLC33A1. Cell Discov 11, 36 (2025) https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/620fe182-686b-41db-b9dc-10b8881f2b9c/Salipro-TbAQP2-Melarsoprol.gif Structure Gallery M. Matusevicius, R. A. Corey, M. Gragera, K. Yamashita, T. Sprenger, et al., Insights from aquaporin structures into drug-resistant sleeping sickness. eLife 14:RP107460 (2025). https://www.salipro.com/pipeline daily 0.75 2024-07-02 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/0418854c-4cf5-48bd-8165-970cd9c33180/Pipeline.jpg Pipeline https://www.salipro.com/partnering daily 0.75 2023-07-10 https://www.salipro.com/careers daily 0.75 2024-11-22 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/2fd2abe7-8a78-4acf-afa3-e08cb79b9f59/scientists_orig.png https://www.salipro.com/contact daily 0.75 2022-07-05 https://www.salipro.com/privacy-policy daily 0.75 2020-09-01 https://www.salipro.com/cookies daily 0.75 2020-09-01 https://www.salipro.com/application-note-spr daily 0.75 2022-07-05 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1599068071983-H21J485MOX988FSAXHCP/AN_SPR.jpg Application Note SPR https://www.salipro.com/download-application-note-spr daily 0.75 2020-09-09 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1599068071983-H21J485MOX988FSAXHCP/AN_SPR.jpg Download Application Note SPR https://www.salipro.com/application-note-directmx daily 0.75 2022-07-05 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1599643385651-GA0YI43WT6TDYGU0QXWR/AN_DirectMX.jpg Application Note DirectMX https://www.salipro.com/download-application-note-directmx daily 0.75 2020-09-09 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1599643473939-BOGV7JQOYUJYRHMNRRMI/AN_DirectMX.jpg Download Application Note DirectMX https://www.salipro.com/application-note-antibody daily 0.75 2022-07-05 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1599643893265-WHVI2NINT42CQGEIP5LQ/AN_Ab.jpg Application Note Antibody https://www.salipro.com/download-application-note-antibody daily 0.75 2020-09-09 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1599644030671-K1QI57EJ163K4J7QC2DH/AN_Ab.jpg Download Application Note Antibody https://www.salipro.com/application-note-gen daily 0.75 2022-07-05 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1629798364945-SZ0U8K1ZKPWISSCW37M2/GEN_PhageDisplay.jpg Application Note GEN https://www.salipro.com/download-application-note-gen daily 0.75 2021-08-24 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/1629799539176-YFN8HLUNDS2B4GPG37PO/GEN_PhageDisplay.jpg Download Application Note GEN https://www.salipro.com/download-application-note-pannexin1 daily 0.75 2022-03-10 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/d72d8c8d-6983-4110-8279-dfc5223b7918/AN_Pannexin1.png Download Application Note Pannexin1 https://www.salipro.com/application-note-pannexin1 daily 0.75 2022-07-05 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/eca3661a-7fa0-43b8-890d-8aeefdeff94e/AN_Pannexin1.png Application Note Pannexin1 https://www.salipro.com/antibody-discovery daily 0.75 2026-01-28 https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/acb48745-4e66-4ec1-8a66-1cdb92515935/AN_Ab.jpg Salipro® for Antibody Discovery https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/97e19684-2a17-48c7-b244-4230b1b6518b/GEN_PhageDisplay.jpg Salipro® for Antibody Discovery https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/4eff5b3b-257e-4ecc-90cf-519ccd087a99/Screenshot+2025-10-23+at+09.39.05.png Salipro® for Antibody Discovery https://images.squarespace-cdn.com/content/v1/5f05d277022f01727f2925c3/09ac5f10-929a-4bd8-ab87-9db8426cd653/Picture+1.jpg Salipro® for Antibody Discovery - 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