New Publication- Unraveling the Code of Brain Ion Channels with Salipro®

A new exciting study published in the British Journal of Pharmacology sheds new light on the modulation of pentameric ligand-gated ion channels (pLGICs), a key target for many therapeutics.

Understanding how these molecules modulate the function of pLGICs is vital for developing novel drugs for a range of neurological disorders. In this work, the Salipro® platform enabled the researcher to capture a detailed view of a pentameric ligand-gated ion channel (sTeLIC) interacting with stimulant-like molecules. 

This new research opens up new avenues for the design of next-generation drugs targeting these important receptors.

A few key takeaways from the study:

• A New Druggable Site: This research reveals a novel modulatory site on a key brain receptor that can be targeted by new drugs.

• Smarter Drug Design: The detailed structural blueprint from this study will help create more precise medicines with fewer side effects for neurological and psychiatric disorders.

• Deeper Brain Insights: This work provides a more complete picture of how these ion channels function, offering valuable clues into brain health and disease.

Congratulations to the teams at Stockholm University, KTH Royal Institute of Technology, and Institut Pasteur for their significant contribution to the field of pharmacology and structural biology!

Find the full study:
E. Karlsson, et al., Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel. British Journal of Pharmacology,  182(12),  2790–2802 (2025).